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Achievements and challenges in controlling Chagas disease
Rodríguez-Morales, Alfonso J.; Von, Anna; Franco-Paredes, Carlos.
  • Rodríguez-Morales, Alfonso J.; Universidad de Los Andes. Instituto Experimental José Witremundo Torrealba. VE
  • Von, Anna; Universidad de Los Andes. Instituto Experimental José Witremundo Torrealba. VE
  • Franco-Paredes, Carlos; Universidad de Los Andes. Instituto Experimental José Witremundo Torrealba. VE
Bol. méd. Hosp. Infant. Méx ; 68(2): 111-119, mar.-abr. 2011.
Artigo em Inglês | LILACS | ID: lil-700901
ABSTRACT
American trypanosomiasis or Chagas disease continues to endanger the lives of many million people in Latin America, and through travel and population migration there is a risk of congenital cases in nonendemic settings. Substantial improvements in the transmission of the disease have been achieved through vector control and blood-bank screening. However, vector-borne transmission remains the main mode of acquisition of infection in many settings coupled with congenital transmission and food-borne and accidental exposure through transplantation or laboratory exposure. The main sites of affection include the heart and gastrointestinal tract. Antiparasitic treatment of indeterminate forms is successful in many cases by delaying the risk of progression of cardiomyopathy, but treatment of chronic chagasic cardiomyopathy remains mainly supportive. The BENEFIT trial that will be completed by late 2011 or early 2012 will provide evidence for or against treating chronic symptomatic forms. Control or eliminating Chagas disease transmission coupled with decreasing the associated burden of disease in Latin America will promote better health and social and economic development among the most impoverished populations in the region.

Texto completo: DisponíveL Índice: LILACS (Américas) Idioma: Inglês Revista: Bol. méd. Hosp. Infant. Méx Assunto da revista: Pediatria Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Venezuela Instituição/País de afiliação: Universidad de Los Andes/VE

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Texto completo: DisponíveL Índice: LILACS (Américas) Idioma: Inglês Revista: Bol. méd. Hosp. Infant. Méx Assunto da revista: Pediatria Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Venezuela Instituição/País de afiliação: Universidad de Los Andes/VE