A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
36(1): 89-94, Jan-Mar. 2014. tab
Artigo
em Inglês
| LILACS
| ID: lil-702629
ABSTRACT
Objective: To understand the risks of posttraumatic stress disorder (PTSD) development in the next generation of PTSD patients, we conducted a review on the biological, but not genetic, evidence of transgenerational transmission of PTSD vulnerability. Methods: Pertinent articles published from 1985 to September 2011 were searched using online academic search engines, including MEDLINE, EMBASE, ScienceDirect, OVID, PsycLIT, and SCOPUS, and a non-systematic review was conducted. Results: There is paradoxical evidence that hypothalamic-pituitary-adrenal axis changes in PTSD patients may also be evident in their offspring. This effect and biological vulnerability to PTSD may be transmitted across generations through maternal epigenetic programming during pregnancy. The samples of most studies, which were not large enough and represented the outcome of few research groups, consisted of a specific type of patients with a particular trauma. Conclusions: There is still a need to conduct studies in other geographical areas with different genetic background and larger samples considering different types of trauma other than those specified in the current literature, so as to strengthen the evidence of transgenerational transmission of PTSD vulnerability. .
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Transtornos de Estresse Pós-Traumáticos
/
Hidrocortisona
/
Relação entre Gerações
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
/
Gravidez
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
Irã
Instituição/País de afiliação:
Mazandaran University of Medical Sciences/IR
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