Immune responses to Leptospira infection: roles as biomarkers for disease severity
Braz. j. infect. dis
;
18(1): 77-81, Jan-Feb/2014. graf
Artigo
em Inglês
| LILACS
| ID: lil-703044
ABSTRACT
Various leptospiral components have been identified and shown to be involved in tissue destruction. In addition, immune responses to leptospires have been implicated in target organ damages in severe leptospirosis cases. Several inflammatory mediators were shown to be higher in susceptible animals than in resistant hosts. Moreover, cytokines/chemokines and serum proteins induced following Leptospira infection were suggested to be biomarkers for disease severity in human leptospirosis. This review focuses on the role of immune responses in the severity of leptospirosis. Studies in both animal models and humans are discussed.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Citocinas
/
Imunidade Inata
/
Leptospirose
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2014
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Tailândia
Instituição/País de afiliação:
Chulalongkorn University/TH
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