Adjuvant effects of classical music on simvastatin induced reduction of anxiety but not object recognition memory in rats
Psychol. neurosci. (Impr.)
;
6(3): 403-410, July-Dec. 2013. graf
Artigo
em Inglês
| LILACS
| ID: lil-703104
ABSTRACT
Simvastatin is one of many hydroxymethylglutaryl-coenzyme-A reductase inhibitors that are prescribed to lower cholesterol. Some emerging evidence indicates that classical music can serve as an effective adjuvant in rats treated with simvastatin. Moreover, simvastatin and classical music have been shown to influence some cognitive functions. To further understand the mechanisms of action, we exposed rats to classical music for 1 month, and then treated them orally with simvastatin. The behavioral experiments suggested that exposure to subchronic simvastatin (1 or 10 mg/kg/day) reduced anxiety levels in the elevated plus-maze and open-field test in rats exposed to Mozart music. The recognition object test results indicated that simvastatin altered non-spatial working memory only at the 1 mg/kg/day dose and improved both short- and long-term object recognition. No significant differences were found between Mozart music and silence in the object recognition test, suggesting that music did not significant affect learning and memory in adult rats. We hypothesize that the anxiolytic, but not object-recognition memory, effects of simvastatin and classical music occur through similar mechanisms, providing an important foundation for future preclinical and clinical research...
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ansiedade
/
Sinvastatina
/
Memória de Longo Prazo
/
Memória de Curto Prazo
/
Música
Limite:
Animais
Idioma:
Inglês
Revista:
Psychol. neurosci. (Impr.)
Assunto da revista:
Neurologia
/
Psicologia
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Regional de Blumenau/BR
/
Universidade da Região de Joinville/BR
/
Universidade do Extremo Sul Catarinense/BR
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