Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
Rev. Soc. Bras. Med. Trop
;
47(1): 90-92, Jan-Feb/2014. tab
Artigo
em Inglês
| LILACS
| ID: lil-703154
ABSTRACT
Introduction:
The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression.Methods:
Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation.Results:
Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis.Conclusions:
HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction. .
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Hepacivirus
/
Hepatite C Crônica
/
Cirrose Hepática
Tipo de estudo:
Estudo diagnóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2014
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal do Para/BR
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