Early and late oral features of chronic graft-versus-host disease
Rev. bras. hematol. hemoter
;
36(1): 43-49, Jan-Feb/2014. tab
Artigo
em Inglês
| LILACS
| ID: lil-703707
ABSTRACT
Background:
Chronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites.Objective:
The aim of this study was to evaluate the oral features of this disease after hematopoietic cell transplantation.Methods:
This was a cross-sectional multicenter study that enrolled patients submitted to transplantation. Oral evaluations used the National Institutes of Health criteria, salivary flow rates, and the range of mouth opening. Pain and xerostomia were evaluated through a visual analogue scale. Patients were divided into two groups based on the transplantation time (up to one year and more than one year).Results:
Of the 57 evaluated recipients, 44 had chronic graft-versus-host disease ten (22.72%) in the group with less than one year after transplantation, and 34 (77.27%) in the group with more than one year after transplantation. Lichenoid/hyperkeratotic plaques, erythematous lesions, xerostomia, and hyposalivation were the most commonly reported oral features. Lichenoid/hyperkeratotic plaques were significantly more common in patients within the first year after the transplant. The labial mucosa was affected more in the first year. No significant changes occurred in the frequency of xerostomia, hyposalivation, and reduced mouth opening regarding time after transplantation.Conclusion:
Oral chronic graft-versus-host disease lesions were identified early in the course of the disease. The changes observed in salivary gland function and in the range of mouth opening were not correlated with the time after transplantation. .
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doença Crônica
/
Transplante de Células-Tronco Hematopoéticas
/
Doença Enxerto-Hospedeiro
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2014
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Instituto Nacional do Câncer/BR
/
Universidade Estadual de Campinas/BR
/
Universidade Federal do Rio de Janeiro/BR
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