Circulating tumor cells: basic concepts and some clinical applications
Appl. cancer res
;
32(4): 142-152, 2012. tab
Artigo
em Inglês
| LILACS, Inca
| ID: lil-706012
ABSTRACT
The spread of cancer requires the presence of circulating tumor cells (CTCs), which are rare cells surrounded by billions of normal hematopoietic cells in the bloodstream. It is believed thatCTCs tend to metastasize to certain organs, thus, their presence may determine invasive tumor behavior. Generally, these cells are undetectable by conventional histopathological analysisand imaging exams with high resolution. Therefore, more sensitive immunohistochemical and molecular assays have been developed that have allowed the specific detection of metastatic tumor cells in regional lymph nodes, peripheral blood and bone marrow. This article reviews theliterature regarding CTCs and tumors of the breast, colorectal, pancreas and lung as it pertains to forms of detection and clinicopathological correlations, in addition to future outlooks
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Imuno-Histoquímica
/
Literatura de Revisão como Assunto
/
Células Neoplásicas Circulantes
Limite:
Humanos
Idioma:
Inglês
Revista:
Appl. cancer res
Assunto da revista:
Neoplasias
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hospital A.C Camargo/BR
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