Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
36(2): 156-167, may. 13, 2014. graf
Artigo
em Inglês
| LILACS
| ID: lil-710208
ABSTRACT
Introduction:
Mitochondrial dysfunction has been postulated to participate in the development of many neuropsychiatric disorders, but there is no consensus as to its role. The aim of this paper is to review recent studies and to outline the current understanding of the association between mitochondrial dysfunction and psychiatric disorders.Methodology:
We reviewed articles that evaluated mitochondrial dysfunction and psychiatric disorders, with a particular focus on depression, bipolar disorder, anxiety disorders, obsessive-compulsive disorder, and autism spectrum disorder, and the association between mitochondrial dysfunction and development of these disorders.Results:
Evidence suggests that alterations in mitochondrial morphology, brain energy metabolism, and mitochondrial enzyme activity may be involved in the pathophysiology of different neuropsychiatric disorders, given their key role in energy metabolism in the cell.Conclusions:
Understanding the interactions between mitochondrial dysfunction and development of psychiatric disorders may help establish more effective therapeutic strategies for these disorders and thus lead to better outcomes for affected subjects. .
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Sistema Nervoso Central
/
Doenças Mitocondriais
/
Transtornos Mentais
/
Mitocôndrias
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade do Extremo Sul Catarinense (UNESC)/BR
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