Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model
Acta cir. bras
;
29(supl.1): 39-44, 2014. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-720397
ABSTRACT
PURPOSE:
To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats.METHODS:
Thirty-eight male Wistar rats were divided into 4 groups normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in saturated and polyunsaturated fatty acids (HF-SP). Blood samples were collected and the penises were removed for histomorphometrical and immunohistochemical analysis.RESULTS:
All high-fat diets promoted an increase in the body mass (p<0.0001). The HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030), and hypercholesterolemia (p=0.0020). Concerning the penis, the high-fat diets led to an increase in the collagen fibers (p<0.0001) and smooth muscle cell density area (p=0.0027), and a decline in the sinusoidal space density area (p<0.0001) and corpus cavernosum cell proliferation (p=0.0003).CONCLUSION:
Diets rich in saturated and/or polyunsaturated fatty acids promoted overweight and induced penile changes in rodent models, which may lead to the development of erectile dysfunction. .
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pênis
/
Ácidos Graxos Monoinsaturados
/
Gorduras na Dieta
/
Dieta Hiperlipídica
/
Disfunção Erétil
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
State University of Rio de Janeiro/BR
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