Immunization of equines with phospholipase A2 protects against the lethal effects of Crotalus durissus terrificus venom
Braz. j. med. biol. res
;
22(4): 509-12, 1989. tab
Artigo
em Inglês
| LILACS
| ID: lil-72499
RESUMO
Equines (2 horses and 2 donkeyes) immunized with whole Crotalus durissus terrificus venom or its phospholipase A2 component either presented an increased survival time determined 3 days after challenge or were totally resistant to a challenging lethal dose of 200 mg crude venom 270 days after the initial immunization or 90 days after the last booster injection. the resistance was demonstrable on the basis of a good correlation with antibody titers determined by the ELISA method but not with the flocculation and neutralization assays. Since phospholipase A2 is essentially montoxic, it can be used as a substitute for whole venom for the production of commercial antisera ad as an immuniaing agent in prophylalctic progams
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Fosfolipases
/
Imunização
/
Venenos de Crotalídeos
/
Crotoxina
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS