Impacto clínico de un sistema de farmacovigilancia activa realizado por un farmacéutico en el reporte y subnotificación de reacciones adversas a medicamentos / Assessment of an active pharmacovigilance system carried out by a pharmacist
Rev. méd. Chile
;
142(8): 998-1005, ago. 2014. graf, tab
Artigo
em Espanhol
| LILACS
| ID: lil-728348
ABSTRACT
Background: Despite the importance of notifying and preventing adverse drug reactions (ADRs), they are under reported and their consequences are not adequately evaluated. Aim: To assess the impact of a pharmacovigilance system carried out by a pharmacist. Material and Methods: In an internal medicine service, the spontaneous report of ADRs was compared blindly with an active pharmacovigilance system in which a pharmacist detected, monitored and prevented ADRs. Results: A total of 1,196 patients was included. Of these 604 were hospitalized in intervened wards, where 50 suspected ADRs in 47 patients were reported. In non-intervened wards, only three ADRs were spontaneously reported. Therefore, the pharmacovigilance system significantly improved the detection and report of ADRs with a risk ratio of 15.4 (95% confidence intervals 4.8-49.1). Sixty six percent of ADRs were classified as severe. Antimicrobials were the main group of medications causing ADRs in 44% of reports. Forty three percent of ADRs were preventable and prolonged hospital stay by a mean of eight days. Conclusions: An active pharmacovigilance system carried out by pharmacists improves the detection of ADRs and promotes its prevention.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Farmacêuticos
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Farmacovigilância
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudos de avaliação
/
Estudo de incidência
/
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Hospital del Salvador/CL
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