Inflammatory cytokines adiponectin, resistin, IL-6 and IFN-γ are associated with insulin resistance in eutrophic and obese children
Bol. méd. Hosp. Infant. Méx
;
71(1): 8-14, ene.-feb. 2014. tab
Artigo
em Inglês
| LILACS
| ID: lil-728503
ABSTRACT
Background: Obesity, a worldwide health problem, is associated with the increase of noncommunicable diseases. Excess adipose tissue above what is expected produces a cytokine imbalance decreasing adiponectin-an anti-inflammatory cytokine-and increasing those proinflammatory cytokines such as resistin, IL-6 and IFN-γ. This imbalance elicits a low-degree systemic inflammation associated with insulin resistance (IR). Therefore, the aim of this study was to determine the relationship between pro- and anti-inflammatory cytokines levels with IR in eutrophic and obese Mexican children. Methods: A cross-sectional study was conducted in 183 school-age children classified as obese and 186 children classified as eutrophic. Adiponectin, resistin, IL-6 and IFN-γ, glucose, insulin, high-density lipoprotein cholesterol and triglycerides were determined from a fasting blood sample. Height, weight, waist circumference, and systolic and diastolic blood pressures were measured. Spearman correlation and linear regression analysis were used to assess the association between cytokines and IR. Results: Anthropometric and metabolic measurements as well as adiponectin concentrations were statistically different between eutrophic and obese children (p <0.001). Adiponectin concentrations were 12.5 ± 5.0 and 10.8 ± 4.2 μg/mL (p <0.018) for obese subjects without IR and obese subjects with IR. Resistin concentrations were 11.7 ± 7.5 and 14.2 ± 7.8 ng/mL (p =0.026), respectively. Linear regression showed that the HOMA-IR decreased -0.04 units (p =0.003) by unit of change of adiponectin. Whereas the association with resistin was opposite, the HOMA-IR units increased 0.02 by unit of change in resistin (p =0.018). Conclusions: In this sample of eutrophic and obese Mexican children, adiponectin concentrations were inversely related with IR contrary to resistin, whose levels were directly related.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Revista:
Bol. méd. Hosp. Infant. Méx
Assunto da revista:
Pediatria
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Secretaría de Salud/MX
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