Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
36(4): 340-343, Oct-Dec/2014. graf
Artigo
em Inglês
| LILACS
| ID: lil-730590
ABSTRACT
Objective:
To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).Methods:
Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).Results:
BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p < 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.Conclusion:
These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD. .
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Transtorno Bipolar
/
Fatores de Crescimento Neural
Tipo de estudo:
Estudos de avaliação
/
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Minas Gerais (UFMJ)/BR
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