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Micro RNA expression and prognosis in low-grade non-invasive urothelial carcinoma
Dip, Nelson; Reis, Sabrina T.; Abe, Daniel K.; Viana, Nayara I.; Morais, Denis R.; Moura, Caio M.; Katz, Betina; Silva, Iran A.; Srougi, Miguel; Leite, Katia R. M..
  • Dip, Nelson; University of Sao Paulo Medical School. Urology Department – LIM55. Laboratory of Medical Investigation. BR
  • Reis, Sabrina T.; University of Sao Paulo Medical School. Urology Department – LIM55. Laboratory of Medical Investigation. BR
  • Abe, Daniel K.; University of Sao Paulo Medical School. Urology Department – LIM55. Laboratory of Medical Investigation. BR
  • Viana, Nayara I.; University of Sao Paulo Medical School. Urology Department – LIM55. Laboratory of Medical Investigation. BR
  • Morais, Denis R.; University of Sao Paulo Medical School. Urology Department – LIM55. Laboratory of Medical Investigation. BR
  • Moura, Caio M.; University of Sao Paulo Medical School. Urology Department – LIM55. Laboratory of Medical Investigation. BR
  • Katz, Betina; University of Sao Paulo Medical School. Urology Department – LIM55. Laboratory of Medical Investigation. BR
  • Silva, Iran A.; University of Sao Paulo Medical School. Urology Department – LIM55. Laboratory of Medical Investigation. BR
  • Srougi, Miguel; University of Sao Paulo Medical School. Urology Department – LIM55. Laboratory of Medical Investigation. BR
  • Leite, Katia R. M.; University of Sao Paulo Medical School. Urology Department – LIM55. Laboratory of Medical Investigation. BR
Int. braz. j. urol ; 40(5): 644-649, 12/2014. tab
Artigo em Inglês | LILACS | ID: lil-731132
ABSTRACT
Purpose To analyze a possible correlation between a miRNA expression profile and important prognostic factors for pTa urothelial carcinomas (UC), including tumor size, multiplicity and episodes of recurrence. Materials and Methods Thirty low-grade non-invasive pTa bladder UC from patients submitted to transurethral resection were studied, in a mean follow-up of 17.7 months. As controls, we used normal bladder tissue from five patients submitted to retropubic prostatectomy to treat benign prostatic hyperplasia. Extraction, cDNA and amplification were performed for 14 miRNAs (miR-100, -10a, -21, -205, -let7c, -143, -145, -221, -223, -15a, -16, -199a and -452) using specific kits, and RNU-43 and -48 were used as endogenous controls. Statistical tests were used to compare tumor size, multiplicity and episodes of recurrence with miRNAs expression profiles. Results There was a marginal correlation between multiplicity and miR-let7c over-expression. For all others miRNA no correlation between their expression and prognostic factors was found. Conclusion We did not find differences for miRNAs expression profiles associated with prognostic factors in tumor group studied. The majority of miRNAs are down-regulated, except miR-10a, over-expressed in most of cases, seeming to have increased levels in tumor with more unfavorable prognostic factors. More studies are needed in order to find a miRNA profile able to provide prognosis in pTa UC to be used in clinical practice. .
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Neoplasias Ureterais / Neoplasias da Bexiga Urinária / Carcinoma / MicroRNAs Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2014 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: University of Sao Paulo Medical School/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Neoplasias Ureterais / Neoplasias da Bexiga Urinária / Carcinoma / MicroRNAs Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2014 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: University of Sao Paulo Medical School/BR