Factors associated with inspiratory muscle weakness in patients with HIV-1
Braz. j. infect. dis
;
19(1): 1-7, Jan-Feb/2015. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-741247
ABSTRACT
Background:
the impact of human immunodeficiency virus type 1 (HIV-1) on lung function is well known and associated with a reduction in pulmonary ventilation. Moreover, the use of highly active antiretroviral therapy has been associated with mitochondrial dysfunction and decreased muscle strength. However, there is scarce information about the factors associated with inspiratory muscle weakness in these patients.Objective:
the purpose of the present study was to investigate the factors associated with inspiratory muscle weakness in patients with HIV-1.Methods:
two-hundred fifty seven patients with HIV-1 were screened and categorized into two groups (1) IMW+ (n = 142) and (2) IMW-(n = 115). Lung function (FEV1, FVC and FEV1 /FVC), maximum inspiratory pressure, distance on the six-minute walk test and CD4 cell count were assessed.Results:
the mean duration of HIV infection was similar in the two groups. The following variables were significantly different between groups mean duration of highly active antiretroviral therapy (81 ± 12 in IMW+ versus 38 ± 13 months in IMW-; p = 0.01), and CD4 cell count (327 ± 88 in IMW+ versus 637 ± 97 cells/mm3 in IMW-; p = 0.02). IMW+ presented reduced lung function (FEV1, FVC, FEV1/FVC).Conclusion:
patients with IMW+ had lower distance on the six-minute walk test in comparison to the IMW- group. The duration of highly active antiretroviral therapy, distance traveled on the 6MWT and CD4 count were determinants of IMW in patients with HIV. .
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Músculos Respiratórios
/
Infecções por HIV
/
Debilidade Muscular
/
Fármacos Anti-HIV
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo de etiologia
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2015
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Bom Pastor Health Center Unit/BR
Similares
MEDLINE
...
LILACS
LIS