Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
J. venom. anim. toxins incl. trop. dis
;
21: 1-7, 31/03/2015.
Artigo
em Inglês
| LILACS
| ID: lil-741602
ABSTRACT
Background: Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. Methods: We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. Results: Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics. Conclusion: Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Imunização Passiva
/
Doença pelo Vírus Ebola
/
Prevenção de Doenças
País/Região como assunto:
África
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2015
Tipo de documento:
Artigo
País de afiliação:
França
/
México
/
Estados Unidos
Instituição/País de afiliação:
National Autonomous University of Mexico/MX
/
Paris Descartes University/FR
/
University of Arizona/US
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