Efeito das fraçöes I, II, III e IV do princípio ativo (parotin) sobre o consumo de oxigênio pelo tecido adiposo epididimal de ratos normais e diabéticos / Effects of parotin fractions I, II, III and IV on the orygen consuption by epididimal fat tissues of normal and diabetic rats

RESUMO

Epididymal fat tissues of normal and diabetic rats where utilized to investigate the effect of the "Parotin" four fractions (I, II, III e IV) on oxygen consumption. Two groups of animals were tested group I - Control group (35 animals) and group II - Experimental diabetic group (35 animals). Epididymal fat tissues were removed, incubated in Warburg flasks in presence of Glucose, Glucose ñ Insulin and Glucose ñ Parotin fractions I, II, III and IV. The results showed that the fraction II and III increased significantly the oxygen cocnsumption in fat tissue from normal and diabetic animals. The mentioned fractions, as well as insulin, were also more effective in diabetic animals