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Selenium protects cerebral cells by cisplatin induced neurotoxicity
Karavelioglu, Ergun; Boyaci, Mehmet Gazi; Simsek, Nejdet; Sonmez, Mehmet Akif; Koc, Rabia; Karademir, Mustafa; Guven, Mustafa; Eser, Olcay.
  • Karavelioglu, Ergun; Afyon Kocatepe University. Department of Neurosurgery. Afyonkarahisar. TR
  • Boyaci, Mehmet Gazi; Afyon Kocatepe University. Department of Neurosurgery. Afyonkarahisar. TR
  • Simsek, Nejdet; Afyon Kocatepe University. Department of Neurosurgery. Afyonkarahisar. TR
  • Sonmez, Mehmet Akif; Afyon Kocatepe University. Department of Neurosurgery. Afyonkarahisar. TR
  • Koc, Rabia; Afyon Kocatepe University. Department of Neurosurgery. Afyonkarahisar. TR
  • Karademir, Mustafa; Afyon Kocatepe University. Department of Neurosurgery. Afyonkarahisar. TR
  • Guven, Mustafa; Afyon Kocatepe University. Department of Neurosurgery. Afyonkarahisar. TR
  • Eser, Olcay; Afyon Kocatepe University. Department of Neurosurgery. Afyonkarahisar. TR
Acta cir. bras ; 30(6): 394-400, 06/2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-749642
ABSTRACT

PURPOSE:

To evaluate the central nervous system toxicity of cisplatin and neuroprotective effect of selenium.

METHODS:

Twenty-one male Wistar albino rats were divided into three groups control (C), cisplatin (CS), cisplatin and selenium (CSE, n=7 in each group). Cisplatin (12 mg/kg/day, i.p.) was administered to CS and CSE groups for three days. Furthermore, CSE group received 3mg/kg/day (twice-a-day as 1.5 mg/kg) selenium via oral gavage five days before cisplatin injection and continued for 11 consecutive days. The same volumes of saline were administered to C group intraperitoneally and orally at same time.

RESULTS:

Heterochromatic and vacuolated neurons and dilated capillary vessels in the brain were observed in the histochemical examinations of cisplatin treated group. Rats that were given a dose of 3mg/kg/day selenium decreased the cisplatin induced histopathological changes in the brain, indicating a protective effect. In addition, cytoplasmic staining of the cell for bcl-2, both cytoplasmic and nuclear staining for bax were determined to be positive in the all groups. Bax positive cells were increased in the CS group compared to C group, in contrast to decreased bcl-2 positivity.

CONCLUSION:

Selenium limited apototic activity and histological changes due to the cisplatin related central neurotoxicity. .
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Selênio / Encéfalo / Cisplatino / Neurônios / Antineoplásicos / Antioxidantes Tipo de estudo: Estudos de avaliação / Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Afyon Kocatepe University/TR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Selênio / Encéfalo / Cisplatino / Neurônios / Antineoplásicos / Antioxidantes Tipo de estudo: Estudos de avaliação / Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Afyon Kocatepe University/TR