Striatal dopamine receptor supersensitivity afte long-term haloperiodol treatment of hypophysectomized rats
Braz. j. med. biol. res
;
22(6): 741-3, June 1989. tab
Artigo
em Inglês
| LILACS
| ID: lil-75215
ABSTRACT
Dopamine (DA) receptor sensitivity was studied after long-term treatment with haloperidol (0.5 ad 3.0 mg/Kg, ip, single daily dose) or saline in hypophysectomized and infact rats. Haloperidol treatment for seven days produced a 25 to 125% increase in [3H]-spiroperidol binding to strial DA receptors in a dose-dependent fashion. The increase in binding sits (Bmax) was ximilar in both hypophysectomized and intact rats when compared to controls. The present results show that haloperidol treatment
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Receptores Dopaminérgicos
/
Corpo Estriado
/
Haloperidol
/
Hipofisectomia
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS