Involvement of eicosanoids and PAF in immune-coplex alveolitis
Braz. j. med. biol. res
;
22(6): 745-8, June 1989. tab, ilus
Artigo
em Inglês
| LILACS
| ID: lil-75219
ABSTRACT
An immune-complex-mediated hypersensitivity reaction induced in the rat lung was followed by release of the eicosanoids thromboxane, prostaglandin E2 and leukotriene B4 into bronchoalveolar space. Concomitantly, there was a decrease in the number of circulating platelets. The thrombocytopenia was inhibited by a cyclo-oxygenase inhibitor (indomethacin), a platelet activating factor (PAF) antagonist (BN-52021) and an inhibitor of thromboxane (econazozle), but was not affected by a lipoxygenase inhibitor (NDGA). These results suggest the involvement of eicosanoids and PAF in the immune complex hypersensitivity reaction in the rat lung and indicate the ocurrence of interactions between PAF and thromboxane
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Índice:
LILACS (Américas)
Assunto principal:
Líquido da Lavagem Broncoalveolar
/
Fator de Ativação de Plaquetas
/
Tromboxanos
/
Alveolite Alérgica Extrínseca
/
Complexo Antígeno-Anticorpo
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
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