Mean platelet volume is associated with disease severity in patients with obstructive sleep apnea syndrome
Clinics
;
70(7): 481-485, 2015. tab
Artigo
em Inglês
| LILACS
| ID: lil-752398
ABSTRACT
OBJECTIVE:
Obstructive sleep apnea syndrome is associated with cardiovascular diseases and thromboembolic events. The mean platelet volume (MPV) is a predictor of cardiovascular thromboembolic events. The aim of the present study is to investigate the association between the MPV and disease severity in patients with obstructive sleep apnea syndrome.METHODS:
We prospectively included 194 obstructive sleep apnea syndrome patients without cardiovascular disease (mean age 56.5±12.5 years) who were undergoing sleep tests. An overnight full laboratory polisomnography examination was conducted on each patient. The patients were divided into 3 groups according to the apnea-hypopnea index (AHI) (1) AHIlow group 5≤AHI<15, (2) AHImid group 15<AHI≤30, and (3) AHIhigh group AHI>30.RESULTS:
The highest MPV values were found in the AHIhigh group compared with other groups (p<0.05 for all). Multiple linear regression analysis indicated that the MPV was associated with the AHI (β=0.500, p<0.001) and the high sensitivity C-reactive protein (hs-CRP) level (β=0.194, p=0.010).CONCLUSION:
The MPV is independently associated with both disease severity and inflammation in patients with obstructive sleep apnea syndrome. .
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Contagem de Plaquetas
/
Proteína C-Reativa
/
Apneia Obstrutiva do Sono
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2015
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Adana Numune Training and Research Hospital/TR
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