Resistance of dialyzed patients to erythropoietin
Rev. bras. hematol. hemoter
;
37(3): 190-197, May-Jun/2015. tab
Artigo
em Inglês
| LILACS
| ID: lil-752543
ABSTRACT
Resistance to recombinant human erythropoietin is a common condition in dialyzed patients with chronic kidney disease and is associated with more hospitalizations, increased mortality and frequent blood transfusions. The main cause of hyporesponsiveness to recombinant human erythropoietin in these patients is iron deficiency. However, a high proportion of patients does not respond to treatment, even to the use of intravenous iron, which indicates the presence of other important causes of resistance. In addition to the iron deficiency, the most common causes of resistance include inflammation, infection, malnutrition, inadequate dialysis, and hyperparathyroidism, although other factors may be associated. In the presence of adequate iron stores, other causes should be investigated and treated appropriately.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Eritropoetina
/
Diálise Renal
/
Transplante de Rim
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2015
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hospital Felício Rocho/BR
/
Universidade Federal de Minas Gerais/BR
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