Bioactive glass in cavitary bone defects: a comparative experimental study in rabbits
Acta ortop. bras
;
23(4): 202-207, Jul-Aug/2015. tab, fig
Artigo
em Inglês
| LILACS
| ID: lil-754990
ABSTRACT
OBJECTIVES: To compare bioactive glass and autograft regarding their histomorphometric characteristics. METHODS: The authors conducted a prospective case-control experimental study on animals in order to compare the histomorphometric characteristics of bioactive glass versus autograft. Eight rabbits underwent surgery in which a cavitary defect was created in both proximal femurs. One side was filled with bioactive glass granules and the other, with autograft grafted from the contralateral side. The sides were randomized. Fourteen days after surgery, the animals were euthanized. RESULTS: Histologic analysis revealed that bone neoformation was equivalent among the two groups and the osteoblasts cell-count was higher in the femurs treated with bioactive glass. The osteocytes cell-count, however, was lower. The similarity in bone formation between both groups was consistent to literature findings. CONCLUSION: Bioactive glass is similar to autograft regarding bone neoformation in this animal model of cavitary bone defects. Level of Evidence III, Case-Control Study.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Osteogênese
/
Transplante Autólogo
/
Transplante Ósseo
/
Substitutos Ósseos
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta ortop. bras
Assunto da revista:
Ortopedia
Ano de publicação:
2015
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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