Sphingosine Kinase 1 urothelial expression is increased in patients with neurogenic detrusor overactivity
Int. braz. j. urol
;
41(6): 1141-1147, Nov.-Dec. 2015. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-769751
ABSTRACT
Objectives:
To evaluate the expression of sphingosine kinase 1 (SPK1) in the bladder wall in patients with neurogenic lower urinary tract dysfunction and its association with clinical, urodynamic and pathological features. Materials andMethods:
The expression of SPK1 was studied in bladder wall specimens obtained from cystectomy using immunohistochemistry in ten patients with spinal cord injury (n=8) or multiple sclerosis (n=2) with urodynamically proven neuropathic bladder dysfunction, and in controls (n=5). Inflammation and fibrosis were analysed with histological criteria and SPK1 expression was determined by individual immunohistochemical staining.Results:
Significant increased SPK1 urothelial immunoreactivity was shown in patients compared to control group (p=0.03). By contrast, SPK1 immunoreactivity in patients was significantly decreased in the sub-urothelium, muscles and nerves, p=0.02; 0.01 and 0.003, respectively. Patients with neurogenic detrusor overactivity (NDO) had higher SPK1 urothelium expression than those without any DO (p=0.04).Conclusions:
SPK1 is expressed in the human bladder wall, specifically the urothelium, in bladder specimens from patients with NDO. The role of SPK1 in the pathophysiology of NDO needs further elucidation.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Traumatismos da Medula Espinal
/
Fosfotransferases (Aceptor do Grupo Álcool)
/
Bexiga Urinária Hiperativa
Tipo de estudo:
Estudo de etiologia
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2015
Tipo de documento:
Artigo
País de afiliação:
França
Instituição/País de afiliação:
CHU Rangueil/FR
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