Serum Levels of Trace Elements in Patients with Testicular Cancers
Int. braz. j. urol
;
41(6): 1101-1107, Nov.-Dec. 2015. tab
Artigo
em Inglês
| LILACS
| ID: lil-769762
ABSTRACT
Introduction:
Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials andMethods:
In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9±11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age 27.4±10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20°C until assays.Results:
In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05).Conclusions:
These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Neoplasias Testiculares
/
Oligoelementos
/
Neoplasias Embrionárias de Células Germinativas
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2015
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Yuzuncu Yıl University/TR
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