Enzymatic activation of the carcinogens 2 phenylethylhydrazine and 1,2 dimethylhydrazine to carbon centered radicals
Braz. j. med. biol. res
;
20(6): 865-8, 1987. ilus
Artigo
em Inglês
| LILACS
| ID: lil-77468
RESUMO
Spin-trapping experiments demonstrate that oxidation of 1,2-dimethylhydrazine and 2-phenylethylgydrazine generates a comparable yield of carbon-centered radicals when catalyzed by horseradish peroxidase-H2O2. Using oxyhemoglobin as the catalyst, 2-phenylethylgydrazine oxidation generates ten times carbon-centered radicals than 1,2-dimethylhidrazine oxidation. This results is in agreement with oxygen consumption studies from which the apparent KM values of 8.0 mM and 72 mM were calculated for the oxyhemoglobin-catalyzed oxidation of 2-phenylethylhydrazine and 1,2-dimethylhydrazine, respectively. These differences in metabolic activation of mono- and disubstituted hydrazines may be of importance regarding the carcinogenic properties of these derivatives
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Índice:
LILACS (Américas)
Assunto principal:
Peroxidases
/
Fenil-Hidrazinas
/
Oxiemoglobinas
/
Química
/
Dimetilidrazinas
/
Peroxidase do Rábano Silvestre
/
Metilidrazinas
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1987
Tipo de documento:
Artigo
/
Congresso e conferência
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