Novel nonsense mutation in the katA gene of a catalase-negative Staphylococcus aureus strain
Braz. j. microbiol
;
47(1): 177-180, Jan.-Mar. 2016. tab
Artigo
em Inglês
| LILACS
| ID: lil-775102
ABSTRACT
Abstract We report the first description of a rare catalase-negative strain of Staphylococcus aureus in Chile. This new variant was isolated from blood and synovial tissue samples of a pediatric patient. Sequencing analysis revealed that this catalase-negative strain is related to ST10 strain, which has earlier been described in relation to S. aureus carriers. Interestingly, sequence analysis of the catalase gene katA revealed presence of a novel nonsense mutation that causes premature translational truncation of the C-terminus of the enzyme leading to a loss of 222 amino acids. Our study suggests that loss of catalase activity in this rare catalase-negative Chilean strain is due to this novel nonsense mutation in the katA gene, which truncates the enzyme to just 283 amino acids.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Infecções Estafilocócicas
/
Staphylococcus aureus
/
Catalase
/
Códon sem Sentido
Limite:
Criança, pré-escolar
/
Humanos
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Inglês
Revista:
Braz. j. microbiol
Assunto da revista:
Microbiologia
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Molecular Genetics Subdepartment/CL
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