Thymic extracellular matrix in Down's syndrome
Braz. j. med. biol. res
;
22(8): 971-4, 1989. ilus
Artigo
em Inglês
| LILACS
| ID: lil-77732
ABSTRACT
Dow's syndrome (DS) is associated with cellular and humoral immunological abnormalities, and altered histology of the lymphoid and epithelial compartments of the thymus has been reported. In the present study, we investigated the extracellular matrix (ECM) of six DS thymuses. A novel fibroblast-containing network was demonstrated in the cortical region with anti-fibronectin, anti-type I collagen and anti-type IV collagen antibodies. Rupture sites of the baement membrane were also observed. Since the ECM is essential to normal thymic ontogeny, it is likely that the severe intrathymic ECM structure changes occuring in DS may be linked to abnormal cortical thymocyte depletion
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Timo
/
Síndrome de Down
/
Matriz Extracelular
Limite:
Criança, pré-escolar
/
Humanos
/
Lactente
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
/
Documento de projeto
Similares
MEDLINE
...
LILACS
LIS