Effects of aspirin-like drugs on Walker 256 tumor growth and cachexia in rats
Braz. j. med. biol. res
;
22(8): 1039-42, 1989. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-77753
RESUMO
Several studies have shown the relationship between prostaglandins (PGs) and cell proliferation. Some PGs may trigger cell dibision or are involved in this process. This a=study analyzes the effect of PG biosyntheseis inhibitors on tumor growth in vivo and cachexia in Walker 256 tumor-bearing rats. Indomethacin markedly inhibited tumor growth (95.5% while ibuprofen and aspirin reduced tumor growth by 73.9% and 59.4%, respectively. In addition, all drug-treated rats partially recovered body weight and food intake as compared to the saline-treated group. These findings suggest that PG synthesis inhibitors improve cancer cachexia
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Índice:
LILACS (Américas)
Assunto principal:
Caquexia
/
Carcinoma 256 de Walker
/
Transformação Celular Neoplásica
/
Aspirina
/
Ibuprofeno
/
Indometacina
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
/
Congresso e conferência
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