DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population
Braz. j. microbiol
;
47(2): 389-393, Apr.-June 2016. tab
Artigo
em Inglês
| LILACS
| ID: lil-780843
ABSTRACT
Abstract β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50).
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Tuberculose
/
Polimorfismo de Nucleotídeo Único
/
Beta-Defensinas
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Braz. j. microbiol
Assunto da revista:
Microbiologia
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Federal University of Pernambuco/BR
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