Medical ozone treatment ameliorates the acute distal colitis in rat
Acta cir. bras
;
31(4): 256-263, Apr. 2016. graf
Artigo
em Inglês
| LILACS
| ID: lil-781329
ABSTRACT
PURPOSE:
To investigate the effect of medical ozone treatment on the experimental acute distal colitis in rats.METHODS:
Eighteen rats were randomly distributed into three equal groups; control, acute distal colitis (ADC) without and with medical ozone treatment. Rats in the control group were taken saline. ADC was performed by rectal way with 4% acetic acid in groups 2 and 3, and the group 3 was treated with medical ozone for three weeks both rectally and intraperitoneally. At the twenty second day the distal colons samples were obtained for malondialdehyde and myeloperoxidase, blood samples were obtained to measure the levels of TNF-α and IL-1β levels. Histolopatological examination was evaluated with Ki-67, IL-1β and VEGF immunostaining densities.RESULTS:
There was significant increase in tissue MDA, MPO activity, TNF-α and IL-1β after ozone administration. There was also a significant difference at immunostaining densities of histopathological examination.CONCLUSIONS:
Medical ozone treatment ameliorated the experimental acute distal colitis induced by acetic acid in rats. Its possible effect is by means of decreasing inflammation, edema, and affecting the proliferation and the vascularization.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Oxidantes Fotoquímicos
/
Ozônio
/
Colite Ulcerativa
Tipo de estudo:
Estudos de avaliação
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Antalya Training and Research Hospital/TR
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