Antibacterial properties and healing effects of Melipona scutellaris honey in MRSA-infected wounds of rats
Acta cir. bras
;
31(5): 327-332, May 2016. tab
Artigo
em Inglês
| LILACS
| ID: lil-783794
ABSTRACT
ABSTRACT PURPOSE:
To investigate the antimicrobial, immunological and healing effects of Melipona scutellaris honey on infected wounds of rat skin.METHODS:
Twenty four Wistar rats were distributed in four groups (6-each). The uninfected skin wounds of group I rats were treated daily with saline for 7 days. Uninfected wounds (group II) rats were treated with honey. In group III (treated with saline) and group IV (treated with honey) wounds were inoculated with MRSA ATTC43300. The first bacterial culture was performed 24 hours later. In the 7th day new culture was done, and wound biopsies were used for cytokines dosage and histopathology.RESULTS:
In group I and III rats the CFU/g count of S. aureus in wounds was zero. In group II rats the CFU/g counts in the wound tissue were significantly higher than in wounds of group IV rats. The density histopathological parameters and the expression of TNF-α, IL1-β, Il-6 were significantly higher on wounds of group IV then in the other groups.CONCLUSION:
Honey of Melipona scutellaris was effective in the management of infected wounds, by significant bacterial growth inhibition, enhancement of cytokine expression, and positively influenced the wound repair.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Infecções Estafilocócicas
/
Cicatrização
/
Staphylococcus aureus Resistente à Meticilina
/
Apiterapia
/
Mel
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal do Rio Grande do Norte/BR
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