MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico / MicroRNAs: circulating biomarkers in type 2 Diabetes Mellitus and physical exercise
Rev. méd. Chile
;
144(3): 355-363, mar. 2016. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-784905
ABSTRACT
MicroRNAs are small, non-coding molecules with a crucial function in the cell´s biologic regulation. Circulating levels of miRNAs may be useful biomarkers in metabolic diseases such as type 2 Diabetes Mellitus (DM2), which alters the circulating concentrations of several types of miRNA. Specific serum profiles of these molecules have been identified in high-risk patients before the development of DM2 and its chronic complications. Most importantly, these profiles can be modified with physical exercise, which is crucial in the treatment of metabolic diseases. Acute physical activity alone can induce changes in tissue specific miRNAs, and responses are different in aerobic or non-aerobic training. Muscle and cardiovascular miRNAs, which may play an important role in the adap tation to exercise, are predominantly altered. Even further, there is a correlation between serum levels of miRNAs and fitness, suggesting a role for chronic exercise in their regulation. Thus, miRNAs are molecules of growing importance in exercise physiology, and may be involved in the mechanisms behind the beneficial effects of physical activity for patients with metabolic diseases.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Exercício Físico
/
MicroRNAs
/
Diabetes Mellitus Tipo 2
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Colômbia
Instituição/País de afiliação:
Universidad Nacional de Colombia/CO
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