Bacterial chemistry-III: preliminary studies on Trypanosomal activities of Chromobacterium violaceum products
An. acad. bras. ciênc
;
61(1): 31-6, 1989. tab
Artigo
em Inglês
| LILACS
| ID: lil-78985
ABSTRACT
It has been found that the pigment-I from Chromobacterium violaceum, 3 [1,2 dihydro 5 (5 hydroxy 1H indol 3 yl) 2 oxo 3H pyrrol-3 ylidiene] 1,3 dihydro 2H indol 2 one, has trypanocide activity. The formylated derivatives, pigment-III, immobilized 100% of the Trypanosoma cruzi at a level of 46 micronM after 48h of interaction with a total growth inhibition in the same period. Pigment I exhibited low toxicity and a DNA synthesis inhibition similar to that of Nifurtimox, a known trypanocide compound
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Índice:
LILACS (Américas)
Assunto principal:
Inibidores de Proteases
/
Sequência de Aminoácidos
Idioma:
Inglês
Revista:
An. acad. bras. ciênc
Assunto da revista:
Ciência
Ano de publicação:
1989
Tipo de documento:
Artigo
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