Dysfunctional hyperpolarization-activated cyclic nucleotide-gated ion channels in cardiac diseases
Rev. bras. cir. cardiovasc
;
31(2): 203-206, Mar.-Apr. 2016.
Artigo
em Inglês
| LILACS
| ID: lil-792650
ABSTRACT
Abstract Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are reverse voltage-dependent, and their activation depends on the hyperpolarization of the membrane and may be directly or indirectly regulated by the cyclic adenosine monophosphate (cAMP) or other signal-transduction cascades. The distribution, quantity and activation states of HCN channels differ in tissues throughout the body. Evidence exhibits that HCN channels play critical roles in the generation and conduction of the electrical impulse and the physiopathological process of some cardiac diseases. They may constitute promising drug targets in the treatment of these cardiac diseases. Pharmacological treatment targeting HCN channels is of benefit to these cardiac conditions.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Canais Disparados por Nucleotídeos Cíclicos Ativados por Hiperpolarização
/
Cardiopatias
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. cir. cardiovasc
Assunto da revista:
Cardiologia
/
Cirurgia Geral
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
China Medical University/CN
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