Clinical features and outcomes of diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis in children
Clinics
;
71(9): 550-554, Sept. 2016. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-794644
ABSTRACT
OBJECTIVE:
To investigate the outcomes of childhood diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis (DEP-HSPN) in response to early diagnosis and prompt treatment.METHODS:
Eleven cases of DEP-HSPN in children were investigated in comparison to HSPN without diffuse endocapillary proliferation (non-DEP-HSPN).RESULTS:
DEP-HSPN had a higher prevalence of nephrotic syndrome but a lower prevalence of hematuria compared to non-DEP-HSPN. IgA, IgG and IgM antibody deposition was found in DEP-HSPN by histopathological examination. Proteinuria cleared in all 11 cases through treatment with steroids and/or immunosuppressive drugs. However, half of the DEP-HSPN patients continuously had hematuria after treatment.CONCLUSION:
The early diagnosis and prompt initiation of immunosuppressive treatment based on renal biopsy are important for achieving favorable outcomes.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vasculite por IgA
/
Nefrite
Tipo de estudo:
Fatores de risco
/
Estudo de rastreamento
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Zhejiang University/CN
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