Level of fetal hemoglobin as an indicator of clinical complications in sickle cell anemia
Braz. j. med. biol. res
;
22(11): 1347-53, 1989. tab
Artigo
em Inglês
| LILACS
| ID: lil-83138
RESUMO
The fetal hemoglobin (HbF) level was used as an indicator of the development of severe clinical complications in 89 patients with sickle cell anemia (SCA). HbF was determined by the alkali denaturation technique. The mean HbF level was 6.7 + or - 4.2% (range, 0.7 to 19.2%) of total hemoglobin. Major organ failures were considered to be teerminal events of morbidity and included 8 cerebrovascular accidents, 13 aseptic necroses of the femoral head and 17 leg ulcer episodes. The characteristics of the test, including sensitivity, specificity and positive predictive value were analyzed for different levels of HbF. The overall specificities were 76,76, and 85% for HbF levels >=8,10 and 12%, respectively. The sensitivity of the test was low. The positive predictive value reached 71% for children with HbF >=8%. The data suggest that HbF level may be a useful indicator of the possibility of a patient developing serious clinical complications
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Índice:
LILACS (Américas)
Assunto principal:
Hemoglobina Fetal
/
Transtornos Cerebrovasculares
/
Necrose da Cabeça do Fêmur
/
Anemia Falciforme
/
Úlcera da Perna
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
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