Characterization of the receptors responsible for the diphasic effect of bradykinin in rat duodenum
Braz. j. med. biol. res
;
22(9): 1137-40, 1989. ilus
Artigo
em Inglês
| LILACS
| ID: lil-83190
ABSTRACT
The response of the rat duodenum to bradykinin (BK) consists of relaxant and contractile components, which have been atributed to different receptor types. To characterize the receptor responsible for this diphasic response we studied the effects of BK analogues known to act on B1 or B2 receptors in other systems. DesArg**9-Leu**8-BK and Thi**5,**8DPhe**7-BK presented only relaxant and only contractile effects, respectively, whereas DArgOHyp883Thi**5,**8DPhe**7-BK was a potent antagonist of the relaxation (but not of the contraction) induced by BK. Our results show that the relaxant and contractile components of the rat duodenum's response to BK are due to B2 and B1 receptor subtypes, respectively
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Bradicinina
/
Receptores de Neurotransmissores
/
Duodeno
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
Similares
MEDLINE
...
LILACS
LIS