Substance P injected into the medial preoptic area inhibits sodium, potassium and water urinary excretion: putative modulation of the cholinergic system
Braz. j. med. biol. res
;
22(7): 895-9, 1989. ilus
Artigo
em Inglês
| LILACS
| ID: lil-83287
ABSTRACT
Substance P (SP, 1.5 nmol) injected into the medial preoptic area (MPOA) of conscious, unrestrained, water-loaded male rats induced a significant decrease in urinary sodium, potassium and water excretion. In contrast, a significant natriuretic effect was observed after injection of 0.3 nmol of a specific competitive SP antagonist ([D-Pr**2, D-Trp**7,**9]-substance P). SP partially blocked the carbachol-induced natriuresis in a time-dependent manner. These data indicate a tonic inhibitory action of SP on sodium excretion and suggest a putative modulatory action of SP on the cholinergic system
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Índice:
LILACS (Américas)
Assunto principal:
Potássio
/
Área Pré-Óptica
/
Sódio
/
Água
/
Substância P
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
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