Balloon-induced endothelial denudation promotes deep injury of the arterial wall
Braz. j. med. biol. res
;
22(7): 913-5, 1989. tab
Artigo
em Inglês
| LILACS
| ID: lil-83375
ABSTRACT
To investigate the cellular reactions to arterial injuries and the influence of a cholesterol-rich diet, 18 rabbits underwent endothelial denudation of the abdominal aorta with a balloon catheter. Fourteen animals were fed a 2% cholesterol diet and 4 were fed normal rabbit chow for 8 weeks. In the cholesterolfed group, 6 animals had only the expected intimal lesions; however, 8 animals exhibited different degrees of balloon=induced medial layer injury, with fibrous healing. Similarly, in the control rabbits, 1 had intimal lesions and 3 had both intimal and medial layer lesions. We conclude that removal of the endothelium with a balloon catheter prometes arterial wall injury deeper than expected. This unexpected result could influence the effect of interventions usually employed in experimental atherosclerosis
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LILACS (Américas)
Assunto principal:
Aorta
/
Endotélio Vascular
/
Cateterismo
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
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