Late eosinophil mobilization induced by PAF-acether in the pleural cavity of rats
Braz. j. med. biol. res
;
22(10): 1281-5, 1989. ilus
Artigo
em Inglês
| LILACS
| ID: lil-83390
ABSTRACT
In view of the rapid degradation of PAF in biological fluids, this study was designed to determine if late eosinophil infiltration induced in rats by PAF was deriived from its direct chemotatic action. A significant and selective 5-fold increase in the pleural eosinophil counts was detected 24 h after intrapleural PAF injection. The transfer of 6-h PAF washings to the pleural cavity of recipient rats also induced a 3-fold selective accumulation of eosinophils. The protein synthesis inhibitor cycloheximide abolished the pleural eosinophil migration and the generation of transferable chemotactic activity when administered to donor but not to recipient rats. These findings suggest that a secondary protein mediator accounts for the late eosinophil mobilization induced by PAF
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Pleura
/
Pleurisia
/
Fator de Ativação de Plaquetas
/
Eosinófilos
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
Similares
MEDLINE
...
LILACS
LIS