Influence of nickel chloride on iron deficiency in rats
Bol. estud. méd. biol
;
37(3/4): 95-9, jul.-dic. 1989. tab
Artigo
em Inglês
| LILACS
| ID: lil-88622
ABSTRACT
The present study was designed to investigate the effects of nickel chloride on dietary iron deficiency in rats. The gree of iron deficiency was relatively moderate, but a more generalized anemia occurred in iron deficiency, in absence of nickel chloride. Moderate iron deficiency anemia induced increased lactate-dehydrogenase activity of serum and bone marrow, perhaps related to the decreased production of energy by oxidative means, Nickel chloride, perhaps for its ability to change iron absorption, for the maintenance of bone marrow metabolism and for to increase ceruloplasmin activity, inhibited the alteration on hemoglobin synthesis. Furthermore, nickel chloride possibly for its action on copper content and Cu-Zn superoxide-dismutase activity, inhibits the shortening of the red cell life span, caused by superoxide radicals
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Índice:
LILACS (Américas)
Assunto principal:
Anemias Nutricionais
/
Cloretos
/
Níquel
Limite:
Animais
Idioma:
Inglês
Revista:
Bol. estud. méd. biol
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1989
Tipo de documento:
Artigo
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