Bilateral microinjection of ethosuximide into the substantia nigra does not prevent amygdala-kindled seizures
Braz. j. med. biol. res
;
23(11): 1139-41, 1990. tab
Artigo
em Inglês
| LILACS
| ID: lil-91615
ABSTRACT
Male Wistar rats were sugjected to daily sessions of electrical amygdala kindling until a generalized seixure was observed on five consecutive days. Bilateral microinections (0.5 micronl) of ethosuximide (ETX) (10 pg/micronl) or saline were then administered though guide cannulas into the substantia nigra (pars reticulata). No significant difference was observed between the ETX (N = 8) and saline (N = 8) groups in duration of afterdischarge or in the latency for stage 5 generalized seizures. Our results indicate that ETX applied to the substantia nigra is not effective in suppressing amydala-kindled seizure
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Índice:
LILACS (Américas)
Assunto principal:
Convulsões
/
Substância Negra
/
Etossuximida
/
Tonsila do Cerebelo
/
Excitação Neurológica
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1990
Tipo de documento:
Artigo
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