Some clacium channel antagonists have no effect on the open-fied behavior of rats nor do they interact with cocaine

RESUMO

The behavioral effects of the calcium channel antagonists nifedipine (10 mg/Kg), diltiazem (10mg/Kg) and verapamil (10mg/Kg) administered intraperitoneally alone or in combination with the CNS stimulant cocaine (20mg/Kg) were investigated in rats using the open-field test. Calcium channel antagonists alone or combined with cocaine produced no significant effects on the number of rearing or number of ambulations. Cocaine inected alone significantly increased the frequency of ambulation. These data indicate that some calciun channel antagonists were not able to alter the behavioral effects induced by cocaine in rats in the open-field and thus do not support the view that calcium antagonists can reverse the effects of psychostimulant drugs