The role of opioids in the analgesic response of rats during the estrous cycle
Braz. j. med. biol. res
;
23(11): 1157-9, 1990. tab
Artigo
em Inglês
| LILACS
| ID: lil-91619
ABSTRACT
The analgesic response was evaluated by the tail immersion test in female rats during each phase of rhe estrous cycle. The reaction time (mean ñ SEM) for tail witdrawal from the hot water bath was faster during proestrus (5.78 ñ 0,28s) and decreased significantly during estrus (5.31 ñ 0.30s) and diestrus 1 (5.40 ñ 0.21s). Blockade of opiate receptors with naloxone (2mg/Kg, ip) invreased the sensitivity to the noxious stimulus only during proestrus (6.46 ñ 0.42 vs 5.02 ñ 0.41 s). These results suggest that the effects of gonadal steroids on nociception may involve an opioid pathway
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Índice:
LILACS (Américas)
Assunto principal:
Estro
/
Analgesia
/
Naloxona
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1990
Tipo de documento:
Artigo
/
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