Endogenous hyperinsulinemia and release of growth hormone following a glucose load as well as in reponse to thyrotropin relasisng hormone in acromegaly
Braz. j. med. biol. res
; 23(10): 953-7, 1990. ilus, tab
Article
em En
| LILACS
| ID: lil-91631
Biblioteca responsável:
BR26.1
ABSTRACT
This study was designed to determine the relationship between endogenous hyperinsulinemia or free fatty acid (FFA) levels and the abnormal release of growth hormone (GH) during the oral glucose tolerance test (OGTT) or in response to thyrotropin releasing hormone (TRH) in acromegalic patients. Seventeen patients with acromegaly and nine healthy control subjects were studied. The 12 acromegalic patients who did not show the paradoxical response of increased GH secretion to the OGTT an/or to TRH exhibited higher insulin levels (total area under the curve during the OGTT) than patients who did. However, the FFA levels of the groups of acromegalic patients were similar. These data suggest that the endogenous hyperinsulinemia exhibited by many patients with acromegaly is associated with the absence of the paradoxical increase in GH secretion during the OGTT and/or after TRH
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Índice:
LILACS
Assunto principal:
Acromegalia
/
Hormônio do Crescimento
/
Hormônio Liberador de Tireotropina
/
Insulina
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1990
Tipo de documento:
Article
/
Congress and conference