Effects of chronic treatment with high doses of chlorpromazine on ATP and ADP hydrolysis by synaptosomal fractions from the rat caudate nucleus
Braz. j. med. biol. res
;
23(10): 969-73, 1990. tab
Artigo
em Inglês
| LILACS
| ID: lil-91634
ABSTRACT
Several studies have indicated that chlorpromazine and its metabolites affect ATP hydrolysis by brain and liver plasma membranes in vitro. The present report examines whether chronic treatment (12 days) with high doses of chlorpromazine (10 and 40 mg/kg) could affect ATP and ADP hydrolysis by synaptosomal fractions from the rate caudate nucleus. Both doses of chlorpromazine caused significant and paralled decreases (23 to 31%) in the ATP and ADP hydrolysis. The parallelism between the effects of chlorpromazine on ATP and ADP hydrolys suggests the participation of a single enzyme (ATP diphosphohydrolase) in nucleotide hydrolysis
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Índice:
LILACS (Américas)
Assunto principal:
Sinaptossomos
/
Núcleo Caudado
/
Difosfato de Adenosina
/
Trifosfato de Adenosina
/
Clorpromazina
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1990
Tipo de documento:
Artigo
/
Congresso e conferência
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