Praziquantel inhibits Schistosoma mansoni attachment in vitro
Braz. j. med. biol. res
;
23(10): 1005-8, 1990. ilus
Artigo
em Inglês
| LILACS
| ID: lil-91641
ABSTRACT
Male adult Schistosoma mansoni worms were placed in a glass dish containing Tyrode solution and observed for 15 min after addition of praziquantel (0.01 to 1 pmicron M). Praziquantel promoted a concentrationp- and time-dependent inhibition of sucker-mediated attachment of the worm. Attachment inhibition was correlated with shortening of the parasite. We propose that the rapid and total inhibition of worm attachment observed in vitro with 1 micronM praziquantel indicates that therapeutic concentrations of this drug should promote a rapid hepatic shift, in vivo, which may facilitate host tissue reaction
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Índice:
LILACS (Américas)
Assunto principal:
Praziquantel
/
Schistosoma mansoni
/
Técnicas In Vitro
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1990
Tipo de documento:
Artigo
/
Congresso e conferência
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