Depressed adjuvant arthritis in rats transferred with spleen cells from Trypanosoma cruzi-infected syngeneic donors
Braz. j. med. biol. res
;
23(6/7): 567-71, 1990. ilus
Artigo
em Inglês
| LILACS
| ID: lil-92204
ABSTRACT
In the present we investigated whether the attenuating effect of chronica Trypanosoma cruzi (Tc) infection on adjuvant arthritis (AA) in the rat could be transferred to naive recipients. Transfer of whole spleen cells, but not of serum, from Tc-infected rats reduced AA (x ñ SEM 11 ñ 0.5) in recipient animals (control values, x ñ SEM 19 ñ 0.7). Transfer of a T-cell enriched subpopulation from spleen cells of Tc-infected rats (obtained by filtration through a nylon column) resulted in a similar attenuationb of AA (x ñ SEM 7.5 ñ 2.2). The arthritic response of rats intraperitoneally inoculated with 2 x 10**5 Tc 48h before induction did not differ from that observed in controls. Neither parasites nor specific antibodies were observed in suckling mice inoculated with serum or cell suspensions employed in transfer experiments. Consequently, the depressive effect on AA could not be directly attributed to Tc per se. We hypothesize that a homeostatic immunosuppressor mechanism may be responsible for this phenomenon
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Índice:
LILACS (Américas)
Assunto principal:
Artrite Experimental
/
Baço
/
Doença de Chagas
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1990
Tipo de documento:
Artigo
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