Pituitary-testicular axis in benznidazole-treated rata
Braz. j. med. biol. res
;
23(8): 719-22, 1990. tab
Artigo
em Inglês
| LILACS
| ID: lil-92329
RESUMO
Benznidazole is used extensively throughout Latin America as an antiparasitic chemotherapeutic agent against chagasica infection. We have shown that rats chronically treated with 80 mg benznidazole Kg-1 day-1 for 30, days present severe testicular atrophy and arrest of spermatognesis. In the present experiments, plasma levels of testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (Prl- were inbestigated in rats receiving 10, 40 and 80 mg benznidazole Kg-1 day-1 for 30 days. No significant change in T, LH or Prl levels was observed in treated rats (P > 0.05). Plasma FSH concentration, however, was markedly invreased (P < 0.05 by benzidazole treatment (40 and 80 mgKg-1 day-1) and remained high for 90 days after drug treatment was discontinued
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Índice:
LILACS (Américas)
Assunto principal:
Prolactina
/
Testosterona
/
Benzimidazóis
/
Hormônio Luteinizante
/
Hormônio Foliculoestimulante
/
Antiprotozoários
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1990
Tipo de documento:
Artigo
/
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